Adenosine 5'-methylenediphosphate (sodium salt) |
| Katalog-Nr.GC90794 |
Ein Hemmstoff von Ecto-5'-Nukleotidase.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2659222-76-9
Sample solution is provided at 25 µL, 10mM.
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Adenosine 5'-metlenediphosphate is an inhibitor of ecto-5’-nucleotidase, also known as CD73, with a Ki value of 37 nM.1 It inhibits cAMP accumulation induced by adenosine 5'-monophosphate , adenosine 5'-diphosphate , or adenosine 5'-triphosphate , but not adenosine , in VA-13 human fibroblasts when used at a concentration of 100 µM. Adenosine 5'-metlenediphosphate reduces proliferation of U-138 MG glioma cells, as well as inhibits the invasion and migration of MHCC97H hepatocellular carcinoma (HCC) cells in a migration assay.2,3 It increases tumor infiltration of CD3+CD8+ T cells and reduces tumor growth in a K1735 murine melanoma model when administered at a dose of 400 µg/mouse.4
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