AMG 18 hydrochloride (Synonyms: AMG-18 Hydrochloride) |
Katalog-Nr.GC50366 |
AMG 18-Hydrochlorid (AMG-18-Hydrochlorid) ist ein monoselektives IRE1α Inhibitor, der IRE1α allosterisch abschwÄcht; RNase-AktivitÄt mit einem IC50 von 5,9 nM.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2250019-92-0
Sample solution is provided at 25 µL, 10mM.
Potent and selective IRE1α inhibitor (IC50 values are 13 and 99 nM for recombinant and cellular IRE1α, respectively). Exhibits selectivity for IRE1α in a panel of over 100 other kinases.
Harrington et al (2014) Unfolded protein response in cancer: IRE1α inhibition by selective kinase ligands does not impair tumor cell viability. ACS Med.Chem.Lett. 6 68 PMID:25589933
Average Rating: 5
(Based on Reviews and 10 reference(s) in Google Scholar.)GLPBIO products are for RESEARCH USE ONLY. Please make sure your review or question is research based.
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