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Amosulalol

Katalog-Nr.GC70259

Amosulalol (YM 09538) ist ein oral aktiver und dualer Inhibitor des α1/β1-Adrenergic Receptors.

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Amosulalol Chemische Struktur

Cas No.: 85320-68-9

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1 mg
198,00 $
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Sample solution is provided at 25 µL, 10mM.

Description Chemical Properties Product Documents
Amosulalol (YM 09538) is an orally active and dual inhibitor of α1/β1-Adrenergic Receptor. Amosulalol exhibits antihypertensive activity via α1-Adrenergic Receptor inhibition. Amosulalol decreases reflexogenic increases in heart rate and plasma renin activity (PRA) via β1-Adrenergic Receptor inhibition in spontaneously hypertensive rats (SHR).

Amosulalol (3-30 mg/kg; p.o.; single dose) reduces acute systolic blood pressure in hypertensive rats[1].
Amosulalol (50 mg/kg; p.o.; twice daily for 12 weeks) produces an intolerant antihypertensive effect and also reduces central rate and increases PRA in hypertensive rat models[1].

References:
[1]. Honda K, et al. Autonomic and antihypertensive activity of oral amosulalol (YM-09538), a combined alpha- and beta-adrenoceptor blocking agent in conscious rats. Jpn J Pharmacol. 1985 May;38(1):31-41.

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