AQ-13 dihydrochloride |
| Katalog-Nr.GC32313 |
AQ-13-Dihydrochlorid ist ein Aminochinolin-Medikament gegen Malaria, das gegen arzneimittelresistente StÄmme von Plasmodium falciparum wirksam ist.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 169815-40-1
Sample solution is provided at 25 µL, 10mM.
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AQ-13 dihydrochloride is an aminoquinoline antimalarial drug that is effective against chloroquine-resistant strains of Plasmodium falciparum.
Slight decreases in the PCE/RBC ratio are observed in male and female rats treated with CQ and in females only treated with AQ-13; however, none of these changes is statistically significant[1].
[1]. Riccio ES, et al. Genetic toxicology testing of the antimalarial drugs chloroquine and a new analog, AQ-13. Environ Mol Mutagen. 2001;38(1):69-79.
Animal experiment: | Rats[1]Male and female Sprague-Dawley rats are used and are 8-9 weeks of age at the time of dose administration. Micronucleus evaluations are conducted in conjunction with repeatdose toxicity studies. Rats are orally administered AQ-13 or CQ in water. Rats are given a “loading dose” followed by maintenance doses of one-half the loading dose administered 12 hr later and daily thereafter for 6 additional days[1]. |
References: [1]. Riccio ES, et al. Genetic toxicology testing of the antimalarial drugs chloroquine and a new analog, AQ-13. Environ Mol Mutagen. 2001;38(1):69-79. | |
| Cas No. | 169815-40-1 | SDF | |
| Canonical SMILES | CCN(CC)CCCNC1=CC=NC2=CC(Cl)=CC=C12.[H]Cl.[H]Cl | ||
| Formula | C16H24Cl3N3 | M.Wt | 364.74 |
| Löslichkeit | DMSO : 80 mg/mL (219.33 mM) | Storage | Store at -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
|
1 mg | 5 mg | 10 mg |
| 1 mM | 2.7417 mL | 13.7084 mL | 27.4168 mL |
| 5 mM | 0.5483 mL | 2.7417 mL | 5.4834 mL |
| 10 mM | 0.2742 mL | 1.3708 mL | 2.7417 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 29 reference(s) in Google Scholar.)
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