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ARC19499 sodium

Katalog-Nr.GC71242

ARC19499 sodium ist ein Aptamer, das den Gewebefaktor-Pathway-Inhibitor (TFPI) hemmt und dadurch die Initiierung und Ausbreitung von Gerinnseln über den extrinsischen Weg ermöglicht.

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ARC19499 sodium Chemische Struktur

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1 mg
297,00 $
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Sample solution is provided at 25 µL, 10mM.

Description Chemical Properties Product Documents
ARC19499 sodium is an aptamer that inhibits tissue factor pathway inhibitor (TFPI) , thereby enabling clot initiation and propagation via the extrinsic pathway. The core aptamer binds tightly and specifically to TFPI. ARC19499 sodium blocks TFPI inhibition of both factor Xa and the TF/factor VIIa complex. ARC19499 sodium corrects thrombin generation in hemophilia A and B plasma and restores clotting in FVIII-neutralized whole blood.

References:
[1]. Waters EK, Genga RM, Schwartz MC, et al. Aptamer ARC19499 mediates a procoagulant hemostatic effect by inhibiting tissue factor pathway inhibitor.Blood. 2011;117(20):5514-5522.
[2]. Gissel M, Orfeo T, Foley JH, Butenas S. Effect of BAX499 aptamer on tissue factor pathway inhibitor function and thrombin generation in models of hemophilia.Thromb Res. 2012;130(6):948-955.

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