AS 101 (Synonyms: AS101) |
| Katalog-Nr.GC17659 |
AS 101 (AS101), eine immunmodulatorische Tellurverbindung, ist ein starkes IL-1β Inhibitor.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 106566-58-9
Sample solution is provided at 25 µL, 10mM.
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Ammonium tri-chloro(dioxoethylene-O,O′-)tellurate (AS-101), an anti–IL-10 compound, is a nontoxic immunomodulator.
AS101 (0.5-2.5 μg/ml) decreased IL-10 production in a dose-dependent manner. Incubation of RMCL and RMC in the presence of AS101 gradually and significantly decreased mesangial cell proliferation [1]. AS101 (0.5 μg/ml, 1 μg/ml) decreased tyrosine phosphorylation and nuclear translocation of stat3 via inhibition of IL-10 [2]. AS-101 induced proliferation and IL-2 production by human lymphocytes and enhanced the production of IL-2 and colony-stimulating factor by mouse spleen cells. Systemically administration of AS-101 to mice mediated antitumour effects. AS-101 directly enhanced the ratio of OKT4 to OKT8-positive cells in cultured mononuclear cells from AIDS patients [3]. AS101 showed significant bone marrow (BM)-sparing effects and preventd hair loss in chemotherapy-treated patients, with minimal overall toxicity [4]. In mice subjected to cecal ligation and puncture (CLP), treatment with AS101 significantly increased survival of septic mice. AS101 treatment restored the ability of these cells to secrete TNF-α and IL-1β. AS101 increased class II Ag expression on peritoneal macrophages. AS101 increased the level of IFN-γ secreted by splenocytes [5].
References:
[1] Kalechman Y, Sredni B, Weinstein T, et al. Production of the novel mesangial autocrine growth factors GDNF and IL-10 is regulated by the immunomodulator AS101[J]. Journal of the American Society of Nephrology, 2003, 14(3): 620-630.
[2] Kalechman Y, Gafter U, Weinstein T, et al. Inhibition of Interleukin-10 by the Immunomodulator AS101 Reduces Mesangial Cell Proliferation in Experimental Mesangioproliferative Glomerulonephritis ASSOCIATION WITH DEPHOSPHORYLATION OF STAT3[J]. Journal of Biological Chemistry, 2004, 279(23): 24724-24732.
[3] Sredni B, Caspi R R, Klein A, et al. A new immunomodulating compound (AS-101) with potential therapeutic application[J]. Nature, 1987, 330(6144): 173-176.
[4] Sredni B, Albeck M, Tichler T, et al. Bone marrow-sparing and prevention of alopecia by AS101 in non-small-cell lung cancer patients treated with carboplatin and etoposide[J]. Journal of Clinical Oncology, 1995, 13(9): 2342-2353.
[5] Kalechman Y, Gafter U, Gal R, et al. Anti-IL-10 therapeutic strategy using the immunomodulator AS101 in protecting mice from sepsis-induced death: dependence on timing of immunomodulating intervention[J]. The Journal of Immunology, 2002, 169(1): 384-392.
| Cas No. | 106566-58-9 | SDF | |
| Überlieferungen | AS101 | ||
| Chemical Name | Ammonium trichloro[1,2-ethanediolato-O,O']-tellurate | ||
| Canonical SMILES | C1CO[Te](O1)(Cl)(Cl)Cl.[NH4+] | ||
| Formula | C2H4Cl3O2Te.NH4 | M.Wt | 312.05 |
| Löslichkeit | DMF: 30 mg/ml,DMSO: 30 mg/ml,DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml,Ethanol: slightly soluble | Storage | Store at -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
|
1 mg | 5 mg | 10 mg |
| 1 mM | 3.2046 mL | 16.0231 mL | 32.0461 mL |
| 5 mM | 0.6409 mL | 3.2046 mL | 6.4092 mL |
| 10 mM | 0.3205 mL | 1.6023 mL | 3.2046 mL |
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
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- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 38 reference(s) in Google Scholar.)
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