AUTAC1 |
| Katalog-Nr.GC70702 |
AUTAC1 ist ein MetAP2-targeting autophagie-mediated degradator (AUTAC).
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2241669-09-8
Sample solution is provided at 25 µL, 10mM.
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AUTAC1 is a MetAP2-targeting autophagy-mediated degrader (AUTAC). AUTACs contain a degradation tag and a warhead to provide target specificity. AUTAC1 contains an FBnG (p-Fluorobenzyl Guanine) and a Fumagillol moiety. Fumagillol binds covalently to MetAP2.
AUTAC1 (1-100 μM, 24 h) silences endogenous MetAP2 in hela cells[1].
References:
[1]. Daiki Takahashi, et al. AUTACs: Cargo-Specific Degraders Using Selective Autophagy. Mol Cell. 2019 Dec 5;76(5):797-810.e10.
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Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)
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