AZD-1236 (Synonyms: AZD-1236, AZD1236, AZD 1236;) |
| Katalog-Nr.GB62284 |
AZD1236 is a potent and reversible inhibitor of human MMP-9 and MMP-12 (IC50 = 4.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 459814-89-2
Sample solution is provided at 25 µL, 10mM.
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AZD1236 is a potent and reversible inhibitor of human MMP-9 and MMP-12 (IC50 = 4.5 and 6.1nM, respectively), with >10-fold selectivity to MMP-2 and MMP-13 and >350-fold selectivity to other members of the enzyme family. AZD1236 activity is approximately 20 to 50-fold lower at the rat, mouse, and guinea pig orthologues. In acute models of lung injury, AZD1236 inhibited the haemorrhage and inflammation induced by instillation of human MMP-12 into rat lungs by ~80% at 0.81mg/kg, and also abolished macrophage infiltration into BAL fluid induced by tobacco smoke inhalation in the mouse.
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