Azeliragon |
Katalog-Nr.GC19053 |
Azeliragon (TTP488) ist ein oral bioverfÜgbarer Inhibitor des Rezeptors fÜr fortgeschrittene Glykationsendprodukte (RAGE), der sich als potenzielle Behandlung zur Verlangsamung des Krankheitsverlaufs bei Patienten mit leichter Alzheimer-Krankheit (AD) in der Entwicklung befindet.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 603148-36-3
Sample solution is provided at 25 µL, 10mM.
TTP488 is an antagonist at the Receptor for Advanced Glycation End products, is evaluated as a potential treatment for patients with mild-to-moderate Alzheimer's disease (AD).Target: RAGEin vitro: TTP488 is an orally active, centrally acting antagonist of RAGE-RAGE ligand interaction. Chronic oral dosing of TTP488 in AD transgenic mice led to a reduction of amyloid load in the brain, improves performance on behavioral testing and normalization of electrophysiological recordings from hippocampal slices.[1]in vivo: The small molecule RAGE antagonist, TTP488, is developed by Trans-Tech Pharma. The TTP488 or control peptide is administered i.p. daily at a dose of 100 mcg/d.[3] Successful use of the RAGE inhibitor TTP488 in Phase II testing has led to a Phase III clinical trial for AD patients.[2]
References:
[1]. Burstein AH, et al. Effect of TTP488 in patients with mild to moderate Alzheimer's disease. BMC Neurol. 2014 Jan 15;14:12.
[2]. Saito S, et al. New therapeutic approaches for Alzheimer's disease and cerebral amyloid angiopathy. Front Aging Neurosci. 2014 Oct 20;6:290.
[3]. Chen Y, et al. RAGE ligation affects T cell activation and controls T cell differentiation. J Immunol. 2008 Sep 15;181(6):4272-4278.
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