Azido-PEG5-acid |
Katalog-Nr.GC67454 |
Azido-PEG5-Säure ist ein PEG-basierter PROTAC-Linker, der bei der Synthese von PROTACs verwendet werden kann, wie dem Konjugat CPT-APO (CPT: Camptothecin). Azido-PEG5-Säure ist ein nicht spaltbarer PEG-ADC-Linker mit 5 Einheiten, der bei der Synthese von Antikörper-Wirkstoff-Konjugaten (ADCs) verwendet wird.
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Cas No.: 1425973-16-5
Sample solution is provided at 25 µL, 10mM.
Azido-PEG5-acid is a PEG-based PROTAC linker can be used in the synthesis of PROTACs, such as the conjugate CPT-APO (CPT: Camptothecin ). Azido-PEG5-acid is a non-cleavable 5 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1][2].
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2].
[1]. Zolotarskaya OY, et al. Click synthesis of a polyamidoamine dendrimer-based camptothecin prodrug. RSC Adv. 2015;5(72):58600-58608. Epub 2015 Jun 29.
[2]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.
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