Azurin (50-77) (P. aeruginosa) (trifluoroacetate salt) (Synonyms: Azurin p28; p28) |
| Katalog-Nr.GC91474 |
Azurin (50-77) ist ein Peptidfragment des kupferhaltigen bakteriellen Proteins Azurin, das in P. aeruginosa vorkommt und Zellzyklusarrest, Krebsproliferation und angiogeneseregulierende Aktivitäten aufweist.
Products are for research use only. Not for human use. We do not sell to patients.
Sample solution is provided at 25 µL, 10mM.
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Azurin (50-77) is a peptide fragment of the copper-containing bacterial protein azurin, which is found in P. aeruginosa, and has cell cycle arrest, cancer proliferation, and angiogenesis-regulating activities.1,2 It is an inhibitor of VEGFR2 (IC20 = ~10.7 µM).2 Azurin (50-77) (20 µM) induces cell cycle arrest at the G2/M phase in MCF-7 breast cancer cells. It reduces MCF-7 and ZR-75-1 breast cancer cell proliferation when used at a concentration of 50 µM. Azurin (50-77) reduces VEGF-A-induced capillary tube formation (IC50 = 12 µM), as well as decreases cell membrane-associated levels of F-actin, focal adhesion kinase (FAK), and paxillin and increases extracellular levels of platelet endothelial cell adhesion molecule-1 (PECAM-1) in human umbilical vein endothelial cells (HUVECs) when used at a concentration of 25 µM.2 In vivo, azurin (50-77) (10 mg/kg per day) reduces tumor volume in an MCF-7 mouse xenograft model.1
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