BAY-298 |
| Katalog-Nr.GC62861 |
BAY-298 ist ein oral aktiver und selektiver luteinisierender Hormonrezeptor (LH-R)-Antagonist mit IC50-Werten von 96 nM, 23 nM und 78 nM fÜr hLH (humanes LH) und rLH (Ratten-LH) bzw. cLH (Cynomolgus-Affen-LH). .
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2471978-97-7
Sample solution is provided at 25 µL, 10mM.
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BAY-298 is an orally active and selective luteinizing hormone receptor (LH-R) antagonist with IC50s of 96 nM, 23 nM and 78 nM for hLH (human LH) and rLH (rat LH) and cLH (cynomolgus monkey LH), respectively. BAY-298 can reduce sex hormone levels[1].
BAY-298 (oral; 4.5-72 mg/kg/day; for 8 days) dosedependently loweres serum estradiol levels in proestrus[1]. BAY-298 (iv of 0.5 mg/kg or po of 2 mg/kg) has t1/2s of 31 hours and 33 hours for iv and po. And the Cmaxs are 0.28 kg/L and 0.066 kg/L for iv and po[1].
[1]. Wortmann L, et al. Discovery of BAY-298 and BAY-899: Tetrahydro-1,6-naphthyridine-Based, Potent and Selective Antagonists of the Luteinizing Hormone Receptor Which Reduce Sex Hormone Levels In Vivo. J Med Chem. 2019 Oct 31.
Average Rating: 5 (Based on Reviews and 9 reference(s) in Google Scholar.)
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