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BIBX 1382 dihydrochloride

Katalog-Nr.GC50026

Highly selective EGFR-kinase inhibitor

Products are for research use only. Not for human use. We do not sell to patients.

BIBX 1382 dihydrochloride Chemische Struktur

Cas No.: 1216920-18-1

Größe Preis Lagerbestand Menge
10mM (in 1mL DMSO)
36,00 $
Auf Lager
1mg
25,00 $
Auf Lager
5mg
57,00 $
Auf Lager
10mg
98,00 $
Auf Lager
50mg
273,00 $
Auf Lager
100mg
399,00 $
Auf Lager

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Sample solution is provided at 25 µL, 10mM.

Description Chemical Properties Product Documents Related Products

Potent, selective inhibitor of epidermal growth factor receptor (EGFR) tyrosine kinase (IC50 = 3 nM). Displays > 1000-fold lower potency against ErbB2 (IC50 = 3.4 μM) and a range of other related tyrosine kinases (IC50 > 10 μM). Oral administration inhibits growth of established human xenografts in athymic mice.

Dittrich et al (2002) Phase I and pharmacokinetic study of BIBX1382 BS, an epidermal growth factor receptor (EGFR) inhibitor, given in a continuous daily oral administration. Eur.J.Cancer 38 1072 PMID:12008195 |Solca et al (2004) Inhibition of epidermal growth factor receptor activity by two pyrimidopyrimidine derivatives. J.Pharmacol.Exp.Ther. 311 502 PMID:15199094

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