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BPK-29

Katalog-Nr.GC34502

BPK-29 ist ein spezifischer Ligand, der die atypischen Wechselwirkungen zwischen dem nukleÄren Rezeptor NR0B1 und dem Protein (wie RBM45 und SNW1) durch kovalente Modifikation von C274 unterbricht. BPK-29 beeintrÄchtigt das verankerungsunabhÄngige Wachstum von KEAP1-mutierten Krebszellen.

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BPK-29 Chemische Struktur

Cas No.: 2143467-62-1

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Sample solution is provided at 25 µL, 10mM.

Description Chemical Properties Product Documents Related Products

BPK-29 is a covalent small molecule that disrupts NR0B1 complexes and impairs the anchorage-independent growth of KEAP1-mutant cancer cells[1].

BPK-29 substantially engages NR0B1 with good overall proteomic selectivity in KEAP1-mutant Non-Small Cell Lung Cancers[1].

[1]. Woodruff TM,et al. The complement factor C5a contributes to pathology in a rat model of amyotrophic lateral sclerosis. J Immunol. 2008 Dec 15;181(12):8727-34.

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