BPN-15477 |
| Katalog-Nr.GC64420 |
BPN-15477 ist eine potente SMC (Splicing Modulator Compound), die das korrekte Spleißen von ELP1 (Elongator Complex Protein 1) Exon 20 wiederherstellt.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1971086-99-3
Sample solution is provided at 25 µL, 10mM.
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BPN-15477 is a potent SMC (splicing modulator compound) that restores correct splicing of ELP1 (Elongator complex protein 1) exon 20. BPN-15477 corrects splicing of the ELP1 transcript, significantly increases the level of functional protein in vivo in all tissues, including brain. BPN-15477 can be used for frontotemporal dementia research[1].
[1]. Gao D, et al. A deep learning approach to identify gene targets of a therapeutic for human splicing disorders. Nat Commun. 2021 Jun 7;12(1):3332.
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