BRD7-IN-1 |
| Katalog-Nr.GC34505 |
BRD7-IN-1, ein modifiziertes Derivat von BI7273 (BRD7/9-Inhibitor), bindet Über einen Linker an einen VHL-Liganden, um ein PROTAC VZ185 (VZ185 gegen BRD7/9 mit DC50s von 4,5 bzw. 1,8 nM) zu bilden.
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Cas No.: 2448414-48-8
Sample solution is provided at 25 µL, 10mM.
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BRD7-IN-1, a modified derivative of BI7273 (BRD7/9 inhibitor), binds to a VHL ligand via a linker to form a PROTAC VZ185 (VZ185 against BRD7/9 with DC50s of 4.5 and 1.8 nM, respectively)[1]. BRD7, BRD9[1]
[1]. Zoppi V, et al. Iterative Design and Optimization of Initially Inactive Proteolysis Targeting Chimeras (PROTACs) Identify VZ185 as a Potent, Fast, and Selective von Hippel-Lindau (VHL) Based Dual Degrader Probe of BRD9 and BRD7. J Med Chem. 2019 Jan 24;62(2):699-726.
Average Rating: 5 (Based on Reviews and 32 reference(s) in Google Scholar.)
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