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BRD7-IN-2

Katalog-Nr.GC71086

BRD7-IN-2 (Verbindung 2-77) ist ein starker Inhibitor des bromodomain-haltigen Proteins 7 (BRD7), das auf Prostatakrebszellen abzielt.

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BRD7-IN-2 Chemische Struktur

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1 mg
234,00 $
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5 mg
585,00 $
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Sample solution is provided at 25 µL, 10mM.

Description Chemical Properties Product Documents
BRD7-IN-2 (compound 2-77) is a potent inhibitor of bromodomain-containing protein 7 (BRD7), targeting to prostate cancer cells. BRD7-IN-2 is selective for BRD7 rather than BRD9, with IC50s of 5.4 μM, and >300 μM, respectively.

BRD7-IN-2 (compound 2-77) inhibits BRD7 and BRD9 in HEK293T cells, with IC50s of 1.1 μM and 3.2 μM, respectively[1].

References:
[1]. Ordonez-Rubiano SC, Maschinot CA, Wang S, Sood S, Baracaldo-Lancheros LF, Strohmier BP, McQuade AJ, Smith BC, Dykhuizen EC. Rational Design and Development of Selective BRD7 Bromodomain Inhibitors and Their Activity in Prostate Cancer. J Med Chem. 2023 Aug 24;66(16):11250-11270.

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