C18 Ganglioside GD3-d3

C18 Ganglioside G_D3-d₃ is intended for use as an internal standard in the quantification of ganglioside G_D3 by GC- or LC-MS. Ganglioside G_D3 is synthesized by the addition of two sialic acid residues to lactosylceramide and can serve as a precursor to the formation of more complex gangliosides by the action of glycosyl- and sialyltransferases. With roles in cell proliferation and differentiation, its expression increases during development and in pathological conditions such as cancer.¹ Furthermore, the intracellular accumulation of ganglioside G_D3 can contribute to mitochondrial damage, a crucial event during apoptosis.² Ganglioside G_D3 has become a target for therapeutic approaches to prevent malignant properties of tumor cells like melanoma.^1,3 [Matreya, LLC. Catalog No. 2054]

1.Hamamura, K., Furukawa, K., Hayashi, T., et al.Ganglioside GD3 promotes cell growth and invasion through p130Cas and paxillin in malignant melanoma cellsProc. Natl. Acad. Sci. U.S.A.102(31)11041-11046(2005) 2.De Maria, R., Lenti, L., Malisan, F., et al.Requirement for GD3 ganglioside in CD95- and ceramide-induced apoptosisScience277(5332)1652-1655(1997) 3.Nicoll, G., Avril, T., Lock, K., et al.Ganglioside GD3 expression on target cells can modulate NK cell cytotoxicity via siglec-7-dependent and -independent mechanismsEur. J. Immunol.33(6)1642-1648(2003)