C24:1 3'-sulfo Galactosylceramide (d18:1/24:1(15Z)) (Synonyms: (3’-sulfo)Galβ-Cer(d18:1/24:1), N-Nervonoyl Sulfatide, C24:1 Sulfatide, cis-Tetracosenoyl Sulfatide, N-Tetracosenoyl (cis-15) Sulfatide) |
Katalog-Nr.GC43077 |
C24:1 3'-sulfo Galactosylceramide is a member of the sulfatide class of glycolipids.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 151057-28-2
Sample solution is provided at 25 µL, 10mM.
C24:1 3'-sulfo Galactosylceramide is a member of the sulfatide class of glycolipids. It is the predominate sulfatide species in mature myelin, and it accumulates at a higher rate than C24 3'-sulfo galactosylceramide in rat cerebellum from seven to 32 days of age when active myelination occurs. It interacts with C-type lectins and immunoglobulin-like receptors with the highest affinity for LMIR5. It induces production of MCP-1 in basophils but not mast cells and increases the activation of NFAT in a reporter assay via LMIR5. C24:1 3'-sulfo Galactosylceramide is an immunodominant species in myelin, is bound by CD1d in vitro, and increases proliferation in isolated mouse splenocytes. It reduces symptoms and increases survival in a mouse model of chronic relapsing-remitting experimental autoimmune encephalomyelitis (EAE) when used at a dose of 20 µg. It also decreases the number of inflammatory lesions and infiltrating mononuclear cells in the lumbar spinal cord of EAE mice.
Average Rating: 5
(Based on Reviews and 25 reference(s) in Google Scholar.)GLPBIO products are for RESEARCH USE ONLY. Please make sure your review or question is research based.
Required fields are marked with *