CAY10795 |
| Katalog-Nr.GC90701 |
Ein 15-PGDH-Inhibitor
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2241676-74-2
Sample solution is provided at 25 µL, 10mM.
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CAY10795 is a 15-droxy prostaglandin dedrogenase (15-PGDH) inhibitor (IC50 = 3 nM).1 It increases prostaglandin E2 levels greater than 3-fold in IL-1β-stimulated A549 human lung cells when used at a concentration of 500 nM. CAY10795 reduces 15-PGDH activity in the colon of mice when administered at a dose of 20 mg/kg and limits decreases in body weight and colon length and reduces colon ulceration in a mouse model of ulcerative colitis induced by dextran sodium sulfate when administered at a dose of 40 mg/kg. It also accelerates recovery of circulating neutrophils following whole-body radiation and bone marrow transplant in mice when administered at a dose of 10 mg/kg twice per day.
Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)
GLPBIO products are for RESEARCH USE ONLY. Please make sure your review or question is research based.
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