Ceefourin 1 |
Katalog-Nr.GC50287 |
Ceefourin 1 ist ein potenter und hochselektiver Inhibitor des Multidrug-Resistance-Proteins 4 (MRP4). Ceefourin 1 hemmt den Transport eines breiten Spektrums von MRP4-Substraten, ist jedoch gegenÜber anderen ABC-Transportern hochselektiv fÜr MRP4. Ceefourin 1 ist ein Benzothiazol und dient hauptsÄchlich als Chemosensibilisator fÜr Hochrisiko-Neuroblastome.
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Cas No.: 315702-40-0
Sample solution is provided at 25 µL, 10mM.
Selective MRP (multidrug resistance-associated protein) 4 inhibitor (IC50 = 2.6 μM). Selective for MRP4 over P-gp, MRP1 and ABCG2. Sensitizes MRP4 over-expressing cells to SN 38 .
Cheung et al (2014) High-throughput screening identifies Ceefourin 1 and Ceefourin 2 as highly selective inhibitors of multidrug resistance protein 4 (MRP4). Biochem.Pharmacol. 91 97 PMID:24973542
Average Rating: 5
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