cis-BG47 |
| Katalog-Nr.GC70438 |
cis-BG47 ist ein cis-Isomer von BG47, BG47 ist eine prototypische Histondeacetylasen HDAC1 und HDAC2 selektive optoelektive Sonde.
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Sample solution is provided at 25 µL, 10mM.
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cis-BG47 is an cis-isomer of BG47, BG47 is activated to the active cis isomer by 470 nm light[1].
cis-BG47 (BG47) (10 μM, 16 hours) elevates H3K9 acetylation only in the presence of light and also significantly upregulates the expression of haploinsufficiency of progranulin (PGRN) only in the presence of light (25 ms on/75 ms off) in human neural progenitor cells (NPCs)[1].
References:
[1]. Reis SA, et al. Light-controlled modulation of gene expression by chemical optoepigenetic probes. Nat Chem Biol. 2016 May;12(5):317-23.
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