CRAMP (140-173) (mouse) (trifluoroacetate salt) |
| Katalog-Nr.GC90630 |
Ein antimikrobielles Peptid
Products are for research use only. Not for human use. We do not sell to patients.
Sample solution is provided at 25 µL, 10mM.
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Cathelicidin-related antimicrobial peptide (CRAMP) (140-173) is a 34-amino acid peptide derivative of the 38-amino acid antimicrobial peptide CRAMP.1,2 Mature CRAMP is formed from cleavage of the full-length peptide by cathepsin G.3,4 CRAMP (140-173) (1 µg/ml) is active against K. pneumoniae in vitro.1 It decreases neutrophil infiltration of colonic epithelial and luminal surfaces in a porcine model of colitis when administered at a dose of 10 mg/kg.5 Ileal administration of CRAMP (140-173) (10 mg/kg) decreases disease severity and cecal bacterial burden and increases survival in a mouse model of C. difficile infection.6 However, intra-articular administration of CRAMP (140-173) (10 µl of 25 µM) also increases disease severity and induces synovitis in a mouse model of surgery-induced osteoarthritis.7
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