CS1 |
| Katalog-Nr.GB40161 |
TOPO IIα inhibitor with broad-spectrum in vitro antitumor effects (IC50 values 4.3 µM, 11.5 µM, and 4.6 µM for inhibition of proliferation of breast cancer MDA-MB-231, human lung cancer A549 and human cervical cancer HeLa cell lines, respectively). CS1 functions as a Topo II poison to stabilize Topo II/DNA complex, which leads to DNA damage, cell cycle arrest at G2/M phase and apoptosis, and is 6-10-fold less cytotoxic against HL7702 and HUVEC cells compared with etoposide.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1448009-94-6
Sample solution is provided at 25 µL, 10mM.
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TOPO IIα inhibitor with broad-spectrum in vitro antitumor effects (IC50 values 4.3 µM, 11.5 µM, and 4.6 µM for inhibition of proliferation of breast cancer MDA-MB-231, human lung cancer A549 and human cervical cancer HeLa cell lines, respectively). CS1 functions as a Topo II poison to stabilize Topo II/DNA complex, which leads to DNA damage, cell cycle arrest at G2/M phase and apoptosis, and is 6-10-fold less cytotoxic against HL7702 and HUVEC cells compared with etoposide.
Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)
GLPBIO products are for RESEARCH USE ONLY. Please make sure your review or question is research based.
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