D-Proline, 4-hydroxy-, methyl ester hydrochloride |
| Katalog-Nr.GC66216 |
D-Prolin, 4-Hydroxy-, Methylesterhydrochlorid ist ein nicht spaltbarer ADC-Linker, der bei der Synthese von AntikÖrper-Wirkstoff-Konjugaten (ADCs) verwendet wird. D-Prolin, 4-Hydroxy-, Methylesterhydrochlorid ist auch ein Alkylketten-basierter PROTAC-Linker, der bei der Synthese von PROTACs verwendet werden kann[2
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 114676-59-4
Sample solution is provided at 25 µL, 10mM.
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D-Proline, 4-hydroxy-, methyl ester hydrochloride is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). D-Proline, 4-hydroxy-, methyl ester hydrochloride is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1][2
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2].
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