DALDA acetate |
| Katalog-Nr.GC72209 |
DALDA acetate ist ein potenter und hochselektiver μ-Opioid-Rezeptoragonist mit einem Ki von 1,69 nM.
Products are for research use only. Not for human use. We do not sell to patients.
Sample solution is provided at 25 µL, 10mM.
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DALDA acetate carrys a net positive charge (3+) at physiological pH and is thus hydrophilic and more polar than morphine[1].
DALDA acetate (0-7 nmol/rat; i.t.; once) shows antinociceptive and respiratory effects in rats[1].
DALDA acetate (0.1 and 1.0 μg/side; ICV; once) results in biphasic effects, with an initial suppression, an intermediate marked inhibition, followed by activation for horizontal movement, rearing and stereotypy times in rats[2].
References:
[1]. Shimoyama M, et al. Antinociceptive and respiratory effects of intrathecal H-Tyr-D-Arg-Phe-Lys-NH2 (DALDA) and [Dmt1] DALDA. Journal of Pharmacology and Experimental Therapeutics, 2001, 297(1): 364-371.
[2]. Meyer ME, et al. DALDA (H-Tyr-D-Arg-Phe-Lys-NH2), a potent mu-opioid peptide agonist, affects various patterns of locomotor activities. Pharmacol Biochem Behav. 1995 May;51(1):149-51.
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