Daratumumab (Synonyms: Daremuzumab; Anti-Human CD38, Human Antibody) |
Katalog-Nr.GC19785 |
Daratumumab (DARA) ist ein humaner IgG1-mAb, der CD38 anvisiert, ein 46-kDa Typ-II-Transmembran-Glykoprotein, das auf malignen Zellen bei Multiplem Myelom (MM) in hohen Mengen exprimiert wird [1,2].
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Cas No.: 945721-28-8
Sample solution is provided at 25 µL, 10mM.
Daratumumab (DARA) is a human IgG1 mAb targeting CD38, a 46-kDa type II transmembrane glycoprotein that is expressed at high levels on malignant cells in multiple myeloma (MM) [1,2].
Daratumumab elicits cell death through complement-dependent cytotoxicity (CDC), antibody-dependent cell-mediated cytotoxicity (ADCC), antibody-dependent cellular phagocytosis (ADCP), induction of apoptosis, and modulation of CD38 enzyme activities [1]. Macrophages to engulf multiple Daratumumab -opsonized target cells in a relatively short time span with a time-lapse imaging microscopy [1]. Daratumumab -dependent phagocytosis is related to CD38 expression levels, uptake into macrophages and substantial elimination of target cells was consistently observed for CD38-transduced UM9-CD38 and L363-CD38 variants with high levels of CD38 expression [1].
Phagocytosis contributed to the antitumor activity of daratumumab in vivo in 2 different xenograft models: subcutaneous Daudi-luc tumor xenograft model and intravenous leukemic Daudi-luc xenograft model [1]. Daratumumab (8 mg/kg, twice) alone suppressed the tumor growth significantly. And the combination of daratumumab plus lenalidomide was able to reduce the tumor volume [3].
References:
[1]. Overdijk MB, Verploegen S, BÖgels M, van Egmond M, van Bueren JJ, Mutis T, Groen RW, Breij E, Martens AC, Bleeker WK, Parren PW. Antibody-mediated phagocytosis contributes to the anti-tumor activity of the therapeutic antibody daratumumab in lymphoma and multiple myeloma. InMAbs 2015 Mar 4 (Vol. 7, No. 2, pp. 311-320). Taylor & Francis.
[2]. Nooka AK, Kaufman JL, Hofmeister CC, Joseph NS, Heffner TL, Gupta VA, Sullivan HC, Neish AS, Dhodapkar MV, Lonial S. Daratumumab in multiple myeloma. Cancer. 2019 Jul 15;125(14):2364-82.
[3]. Nijhof IS, Groen RW, Noort WA, van Kessel B, de Jong-Korlaar R, Bakker J, Van Bueren JJ, Parren PW, Lokhorst HM, Van De Donk NW, Martens AC. Preclinical evidence for the therapeutic potential of CD38-targeted immuno-chemotherapy in multiple myeloma patients refractory to lenalidomide and bortezomib. Clinical cancer research. 2015 Jun 15;21(12):2802-10.
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