DFMTI (MK5435) (Synonyms: MK5435) |
| Katalog-Nr.GC33154 |
DFMTI (MK5435) kann die Glutamatantwort von rmGlu1 L757V vollstÄndig blockieren.
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Cas No.: 864864-86-8
Sample solution is provided at 25 µL, 10mM.
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DFMTI can completely block the rmGlu1 L757V glutamate response.In vitro: DFMTI can completely block the rmGlu1 L757V glutamate response, although significantly higher concentrations were required to induce blockade.In vivo: DFMTI is efficacious in disrupting prepulse inhibition when dosed orally in rats. DFMTI exhibits a moderate decrease in human potency of approximately 3-fold when compared to rat, exemplified by DFMTI.
[1]. Cho HP et al. A novel class of succinimide-derived negative allosteric modulators of metabotropic glutamate receptor subtype 1 provides insight into a disconnect in activity between the rat and human receptors. ACS Chem Neurosci. 2014 Jul 16;5(7):597-610.
Average Rating: 5 (Based on Reviews and 17 reference(s) in Google Scholar.)
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