DG 041 |
| Katalog-Nr.GC50393 |
DG 041 ist ein potenter, hochaffiner und selektiver EP3-Rezeptorantagonist mit IC50-Werten von 4,6 nM bzw. 8,1 nM im Bindungs- bzw. FLIPR-Assay.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 861238-35-9
Sample solution is provided at 25 µL, 10mM.
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Potent and selective EP3 antagonist (IC50 = 4.6 nM). Inhibits PGE2 facilitation of platelet aggregation in vitro and ex vivo. Displays good plasma and metabolic stability. Does not affect bleeding time in rats. Antiplatelet and antithrombotic.
Markovič et al (2017) Structural features of subtype-selective EP receptor modulators. Drug Discov.Today. 22 57 PMID:27506873 |Singh et al (2009) Antagonists of the EP3 receptor for prostaglandin E2 are novel antiplatelet agents that do not prolong bleeding. ACS Chem.Biol. 4 115 PMID:19193156
Average Rating: 5 (Based on Reviews and 1 reference(s) in Google Scholar.)
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