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DHODH-IN-1

Katalog-Nr.GC70726

DHODH-IN-1 (Verbindung 18d) ist ein potenter Dihydroorotatdehydrogenase (DHODH)-Inhibitor mit einem IC50 von 25 nM.

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DHODH-IN-1 Chemische Struktur

Cas No.: 1800296-63-2

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1 mg
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Sample solution is provided at 25 µL, 10mM.

Description Chemical Properties Product Documents
DHODH-IN-1 (compound 18d) is a potent Dihydroorotate Dehydrogenase (DHODH) inhibitor with an IC50 of 25 nM. DHODH-IN-1 is an inhibitor of pyrimidine biosynthesis pathway.

DHODH-IN-1 (compound 18d) strongly inhibits Jurkat cells proliferation (IC50=0.02 μM)[1].
DHODH-IN-1 (4, 20, 100 nM) blocks the measles virus replication in cells[1].
DHODH-IN-1 (0.008, 0.04, 0.2, 1, 5 μM) increases the expression of an ISRE-luciferase reporter gene when transfecting cells with ssRNA molecules[1].

DHODH-IN-1 (compound 18d) has a t1/2 of 27–41 min[1].

References:
[1]. Lucas-Hourani M, et al.Original 2-(3-Alkoxy-1H-pyrazol-1-yl)azines Inhibitors of Human Dihydroorotate Dehydrogenase (DHODH).J Med Chem. 2015 Jul 23;58(14):5579-98.

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