DHODH-IN-12 |
| Katalog-Nr.GC70741 |
DHODH-IN-12 (Verbindung 12b) ist ein Leflunomid-Derivat und ein schwacher Dihydroorotat-Dehydrogenase (DHODH)-Hemmer mit einem pKa von 5,07.
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Cas No.: 1263303-93-0
Sample solution is provided at 25 µL, 10mM.
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Designed a compound structurally related to Leflunomide, containing the furazan ring (Compound 12a), is designed. Compound 12a undergo ring 4 scission under physiological pH conditions to afford the corresponding cyano-oximes DHODH-IN-12 (Compound 12b). DHODH-IN-12 has been assayed as a DHODH inhibitor; its low potency is probably due to the unfavourable stereochemistry of the oxime substructure[1].
References:
[1]. Giorgis M, et al. 1,2,5-Oxadiazole analogues of leflunomide and related compounds. Eur J Med Chem. 2011 Jan;46(1):383-92.
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