DiBAC4(3) (Synonyms: Bis(1,3-Dibutylbarbituric Acid) Trimethine Oxonol) |
| Katalog-Nr.GC30140 |
DiBAC4(3) ist ein spannungsempfindlicher Fluoreszenzfarbstoff (Λex=490 nm, Λem=505 nm).
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Cas No.: 70363-83-6
Sample solution is provided at 25 µL, 10mM.
DiBAC4(3) is a voltage-sensitive fluorescent dye (λex=490 nm, λem=505 nm).
The membrane hyperpolarization induced by 10 μM Evans blue (EB) in HEKBKα is clearly observed with DiBAC4(3), while the change in membrane potential (MP) by addition of 3 mM tetraethylammonium chloride (TEA) appears more slowly than that measured with microelectrode. The time to peak of hyperpolarization is 2.3±0.9 s (n=4) and 35.0±2.6 s (n=12, P<0.01) by the measurements with microelectrodes and DiBAC4(3), respectively[1].
[1]. Yamada A, et al. Usefulness and limitation of DiBAC4(3), a voltage-sensitive fluorescent dye, for the measurement of membrane potentials regulated by recombinant large conductance Ca2+-activated K+ channels in HEK293 cells. Jpn J Pharmacol. 2001 Jul;86(3):342-50.
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