DMA trihydrochloride |
| Katalog-Nr.GC34098 |
DMA-Trihydrochlorid ist eine fluoreszierende Verbindung (Λex=340 nm, Λem=478 nm).
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Cas No.: 2095832-33-8
Sample solution is provided at 25 µL, 10mM.
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DMA trihydrochloride is a fluorescent compound (λex=340 nm, λem=478 nm).
The newly synthesized bisbenzimidazole derivatives DMA (6c) is evaluated for their cytotoxicity against human tumor cell lines, which are cervix carcinoma cell line (HeLa), breast carcinoma cell line (MCF7) and brain glioma cell line (U87) in comparison to Hoechst. In case of MCF7, the IC50 is observed at 5.3 μM for DMA. The IC50 determined in the case of HeLa is 3.4 μM for DMA[1].
[1]. Singh M, et al. Synthesis and biological activity of novel inhibitors of topoisomerase I: 2-aryl-substituted 2-bis-1H-benzimidazoles. Eur J Med Chem. 2011 Feb;46(2):659-69.
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