DMH2 (Synonyms: VU364849) |
| Katalog-Nr.GC50210 |
DMH2 ist ein potenter BMP-Rezeptorantagonist. DMH2 reguliert die Expression von Id1- und Id3-Proteinen herunter und hemmt die Proliferation und induziert den Zelltod von Lungenkrebs-Zelllinien.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1206711-14-9
Sample solution is provided at 25 µL, 10mM.
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Type I BMP receptor inhibitor (Ki values are <1, 5.4 and 43 nM for ALK6, ALK3 and ALK2, respectively). Exhibits >30-fold selectivity over ALK4, ALK5, BMPR2, AMPK and VEGFR2. Also binds to TGFBR2 (Ki = 85 nM). Decreases growth and induces cell death of H1299 non-small cell lung carcinoma cells in vitro. Enhances liver regeneration in vivo.
Tsugawa et al (2014) Specific AVNreceptor-like kinase 3 inhibitors enhance liver regeneration. J.Pharmacol.Exp.Ther. 351 549 PMID:25271257
Average Rating: 5 (Based on Reviews and 28 reference(s) in Google Scholar.)
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