ent-Tadalafil |
Katalog-Nr.GC39288 |
ent-Tadalafil (ent-IC-351), Verbindung (6S,12aS), ist ein inaktives cis-Enantiomer der Verbindung (6R,12aS). Verbindung (6R,12aS) ist ein potenter PDE5-Inhibitor mit einem IC50 von 0,090 μM, wÄhrend ent-Tadalafil bei Konzentrationen bis zu 10 μM inaktiv ist.
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Cas No.: 629652-72-8
Sample solution is provided at 25 µL, 10mM.
ent-Tadalafil (ent-IC-351), compound (6S,12aS), is a inactive cis-enantiomer of compound (6R,12aS). compound (6R,12aS) is a potent PDE5 inhibitor with an IC50 of 0.090 μM, while ent-Tadalafil is inactive at concentrations up to 10 µM[1].
[1]. Daugan A, et al. The discovery of tadalafil: a novel and highly selective PDE5 inhibitor. 2: 2,3,6,7,12,12a-hexahydropyrazino[1',2':1,6]pyrido[3,4-b]indole-1,4-dione analogues.J Med Chem. 2003 Oct 9;46(21):4533-42.
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