Entecavir Hydrate (Synonyms: BMS 200475, SQ 34,676) |
| Katalog-Nr.GC16092 |
Entecavir-Hydrat (BMS200475-Monohydrat; SQ34676-Monohydrat) ist ein potenter und selektiver Inhibitor von HBV mit einem EC50-Wert von 3,75 nM in HepG2-Zellen.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 209216-23-9
Sample solution is provided at 25 µL, 10mM.
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Entecavir hydrate is a reverse transcriptase inhibitor.
Reverse transcriptase (RT) is used to generate complementary DNA (cDNA) from an RNA template, which is mainly associated with retroviruses, such as HBV.
Entecavir hydrate is an oral antiviral drug used in the treatment of hepatitis B virus (HBV) infection. In 17 patients with hepatitis B virus (HBV) genotype C, treatment with peginterferon
(PEG-IFN) a-2b combination with entecavir hydrate (ETV) for 48 weeks. Among 11 patients exhibited pretherapy HBeAg, 8 showed HBeAg seroconversion. Serum HBV DNA levels reduced by 5.2 and 3.3 log copies/ml by the end of the therapy and follow-up periods, respectively. Intrahepatic cccDNA reduced to 1.4 log copies/mg.
References:
[1]. Hagiwara S, Kudo M, Osaki Y, et al. Impact of peginterferon alpha-2b and entecavir hydrate combination therapy on persistent viral suppression in patients with chronic hepatitis B. J Med Virol, 2013, 85(6): 987-995.
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