Fascaplysin (chloride) (Synonyms: NSC 622398) |
| Katalog-Nr.GC18693 |
Fascaplysin (Chlorid) ist ein antimikrobieller und zytotoxischer roter Farbstoff, der aus dem Meeresschwamm (Fascaplysin (Chlorid)opsis sp.
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Cas No.: 114719-57-2
Sample solution is provided at 25 µL, 10mM.
Fascaplysin is an inhibitor of cyclin D kinase 4/ cyclin D1 (IC50 = 0.35 μM) that was originally isolated from the marine sponge Thorectandra. It is significantly less selective for Cdk6/cyclin D1 (IC50 = 3.4 μM) and does not inhibit other Cdks and tyrosine kinases. Fascaplysin is reported to have antiproliferative activity against retinoblastoma-positive tumor cells, blocking retinoblastoma phosphorylation and inducing G1 arrest. Inhibition of Cdk4 via fascaplysin has been shown to induce peroxisome-proliferator-activated receptor γ-1α deacetylation (IC50 = 0.7 uM) and has been used to demonstrate a role for insulin-activated cyclinD1-Cdk4 signaling in the control of glucose metabolism.
Review for Fascaplysin (chloride)
Average Rating: 5 (Based on Reviews and 20 reference(s) in Google Scholar.)
Review for Fascaplysin (chloride)
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