Ferritin PROTAC DeFer-2 |
| Katalog-Nr.GC91060 |
Ein PROTAC, der den Abbau von Ferritin fördert.
Products are for research use only. Not for human use. We do not sell to patients.
Sample solution is provided at 25 µL, 10mM.
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Ferritin PROTAC DeFer-2 is a proteolysis-targeting chimera (PROTAC) containing oleic acid , which binds to ferritin dimers, conjugated to von Hippel-Lindau ligand , which binds to VHL E3 ligase, via an alkyl linker.1 It induces ferritin degradation in B16/F10 murine melanoma cells when used at a concentration of 0.5 µM, an effect not induced by a negative control with an inverted VHL ligand 1 stereocenter, indicating that the E3 ligase activity of VHL ligand 1 is required for this effect. Ferritin PROTAC DeFer-2 (5 µM) increases intracellular levels of free iron and induces pyroptosis in B16/F10 cells. Ferritin PROTAC De-Fer-2 (10 mg/kg) encapsulated in albumin nanoparticles reduces tumor growth and increases survival in a B16/F10 murine melanoma model.
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