Fustin (Synonyms: Dihydrofisetin, NSC 59264)

Fustin is a polyketide synthase-derived flavanone that has been found in R. verniciflua and has diverse biological activities.^1,2,3,4 It enhances epigallocatechin-3-O-gallate-induced decreases in the viability of U266 multiple myeloma cells when used at concentrations of 5 and 10 µM.² Fustin (50 and 100 mg/kg) inhibits increases in blood glucose levels, as well as serum total cholesterol, triglyceride, and malondialdehyde (MDA) levels, in a mouse model of diabetes induced by streptozotocin .³ It prevents decreases in contextual- and tone fear conditioning freezing time, indicating a reversal of memory deficits, induced by amyloid-β (1-42) (Aβ42) in mice when administered at a dose of 100 mg/kg.⁴

1.MarÍn, L., GutiÉrrez-Del-RÍo, I., Villar, C.J., et al.De novo biosynthesis of garbanzol and fustin in Streptomyces albus based on a potential flavanone 3-hydroxylase with 2-hydroxylase side activityMicrob. Biotechnol.14(5)2009-2024(2021) 2.Kumazoe, M., Fujimura, Y., Yoshitomi, R., et al.Fustin, a flavanonol, synergically potentiates the anticancer effect of green tea catechin epigallocatechin-3-O-gallate with activation of the eNOS/cGMP axisJ. Agric. Food Chem.70(11)3458-3466(2022) 3.Gilani, S.J., Bin-Jumah, M.N., Al-Abbasi, F.A., et al.Fustin ameliorates hyperglycemia in streptozotocin induced type-2 diabetes via modulating glutathione/superoxide dismutase/catalase expressions, suppress lipid peroxidation and regulates histopathological changesSaudi J. Biol. Sci.28(12)6963-6971(2021) 4.Jin, C.-H., Shin, E.-J., Park, J.-B., et al.Fustin flavonoid attenuates β-amyloid (1-42)-induced learning impairmentJ. Neurosci. Res.87(16)3658-3670(2009)