Fz25 |
| Katalog-Nr.GC90660 |
Ein mit Triazol modifiziertes Sterol und ein Antikrebsmittel
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2762498-70-2
Sample solution is provided at 25 µL, 10mM.
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Fz25 is a triazole-modified sterol and an anticancer agent.1 It inhibits the proliferation of A2780 ovarian and HT-29 colorectal cancer cells (IC50s = 15.29 and 15.98 µM, respectively). Fz25 decreases the phosphorylation of EGFR and STAT3 in A2780 cells when used at a concentration of 30.58 µM and phosphorylation of ERK, STAT3, and mammalian target of rapamycin (mTOR) in HT-29 cells at 31.96 µM. It reduces the efflux activity of P-glycoprotein (P-gp), also known as multidrug resistance protein 1 (MDR1), in a reporter assay using HEK293 cells when used at a concentration of 10 µM.
Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)
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