GA3-AM |
| Katalog-Nr.GC50158 |
GA3-AM ist ein zellgÄngiges Analogon des Pflanzenhormons GibberellinsÄure, das als chemischer Dimerisierer oder chemischer Induktor der Dimerisierung wirkt.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1373154-68-7
Sample solution is provided at 25 µL, 10mM.
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Gibberellin-analog (GA3) chemical dimerizer; induces rapid dimerization of GAIs and GID1. GA3-AM crosses the plasma membrane, is cleaved by cytosolic esterase releasing GA3, which then binds GID1- this complex then in turn forms a complex with GAI; this system works on a timescale of seconds (EC50 = 310 nM). GA3 and rapamycin chemically inducible dimerization systems are orthogonal. Cell permeable.
Lin et al (2013) Rapidly reversible manipulation of molecular activities using dual chemical dimerizers Angew.Chem.Int.Ed.Engl. 52 6450 PMID:23649661 |Miyamoto et al (2012) Rapid and orthogonal logic gating with a gibberellin-induced dimerization system Nat.Chem.Biol. 8 465 PMID:22446836
Average Rating: 5 (Based on Reviews and 6 reference(s) in Google Scholar.)
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