BI-4924 |
| Katalog-Nr.GC35515 |
BI-4924 ist ein lipophiler, stark an Plasmaproteine gebundener selektiver Phosphoglyceratdehydrogenase (PHGDH)-Inhibitor (IC50=3 nM) mit ausgezeichneter mikrosomaler sowie hepatozytischer StabilitÄt. Das intrazellulÄre Einfangen von BI-4924 unterbricht die Serinbiosynthese mit einem IC50 von 2200 nM bei 72 h.
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Cas No.: 2244452-09-1
Sample solution is provided at 25 µL, 10mM.
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BI-4924 is a lipophilic, highly plasma protein bound selective phosphoglycerate dehydrogenase (PHGDH) inhibitor (IC50=3 nM) with excellent microsomal, as well as hepatocytic stability. Intracellular trapping of BI-4924 disrupts serine biosynthesis with an IC50 of 2200 nM at 72 h[1]. PHGDH[1]
BI-4924 is a highly potent co-factor nicotinamide adenine dinucleotide (NADH/NAD+)-competitive PHGDH inhibitor. BI-4924 shows high selectivity against the majority of other dehydrogenase targets[1].
[1]. Weinstabl H, et al. Intracellular Trapping of the Selective Phosphoglycerate Dehydrogenase (PHGDH) Inhibitor BI-4924 Disrupts Serine Biosynthesis. J Med Chem. 2019 Jul 31.
Average Rating: 5 (Based on Reviews and 20 reference(s) in Google Scholar.)
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