Calcitriol Derivatives |
| Katalog-Nr.GC35590 |
Calcitriol Derivatives ist ein Vitamin-D3-Analogon.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2070009-24-2
Sample solution is provided at 25 µL, 10mM.
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Calcitriol Derivatives is a vitamin D3 analog. v
[1]. Barrera D, Noyola-MartÍnez N, Avila E, Halhali A, Larrea F, DÍaz L.Calcitriol inhibits interleukin-10 expression in cultured human trophoblasts under normal and inflammatory conditions.Cytokine. 2012 Mar;57(3):316-21. [2]. Lydia A, Asanuma K, Nonaka K, Takagi M, Jeong KH, Kodama F, Asao R, Asanuma E, Prodjosudjadi W, Tomino Y.Effects of 22-oxa-calcitriol on podocyte injury in adriamycin-induced nephrosis.Am J Nephrol. 2012;35(1):58-68. [3]. Michalak K, Wicha J.Total synthesis of a CD-ring: side-chain building block for preparing 17-epi-calcitriol derivatives from the Hajos-Parrish dione.J Org Chem. 2011 Aug 19;76(16):6906-11. [4]. Moorthi RN, Kandula P, Moe SM.Optimal vitamin D, calcitriol, and vitamin D analog replacement in chronic kidney disease: to D or not to D: that is the question.Curr Opin Nephrol Hypertens. 2011 Jul;20(4):354-9. [5]. Yu WD, Ma Y, Flynn G, Muindi JR, Kong RX, Trump DL, Johnson CS.Calcitriol enhances gemcitabine anti-tumor activity in vitro and in vivo by promoting apoptosis in a human pancreatic carcinoma model system.Cell Cycle. 2010 Aug 1;9(15):3022-9.
| Cas No. | 2070009-24-2 | SDF | |
| Canonical SMILES | O[C@H](C/1=C)C[C@@H](CC1=C\C=C2[C@@](CC[C@@H]3[C@@H](CCCC(C)(O)C)C)([H])[C@]3(C)CCC\2)OCCC#N | ||
| Formula | C30H47NO3 | M.Wt | 469.7 |
| Löslichkeit | Soluble in DMSO | Storage | Store at -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
|
1 mg | 5 mg | 10 mg |
| 1 mM | 2.129 mL | 10.6451 mL | 21.2902 mL |
| 5 mM | 0.4258 mL | 2.129 mL | 4.258 mL |
| 10 mM | 0.2129 mL | 1.0645 mL | 2.129 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 4 reference(s) in Google Scholar.)
GLPBIO products are for RESEARCH USE ONLY. Please make sure your review or question is research based.
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