CCR4 antagonist 2 |
| Katalog-Nr.GC35626 |
CCR4-Antagonist 2 (Verbindung 31) ist ein neuartiger potenter, oral bioverfÜgbarer, niedermolekularer Antagonist des CC-Chemokinrezeptors 4 (CCR4), der den Transport von Treg in die Tumormikroumgebung hemmt, ohne die Anzahl von Treg in gesunden Geweben zu unterdrÜcken.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2206788-99-8
Sample solution is provided at 25 µL, 10mM.
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CCR4 antagonist 2 (Compound 31) is a novel potent, orally bioavailable small molecule antagonists of CC chemokine receptor 4 (CCR4) that inhibits Treg trafficking into the Tumor Microenvironment without suppressing the number of Treg in healthy tissues.CCR4 antagonist 2 (Compound 31) exhibits IC50 values of Ca2+flux and (chemotaxis) CTX are 40 nM and 70 nM, respectively[1]. IC50: 40 nM (Ca2+flux); 70 nM (CTX) (CCR4 antagonist 2)[1]
[1]. Jackson JJ, et al. Discovery of a Potent and Selective CCR4 Antagonist That Inhibits Treg Trafficking into the Tumor Microenvironment. J Med Chem. 2019 Jul 11;62(13):6190-6213.
Average Rating: 5 (Based on Reviews and 31 reference(s) in Google Scholar.)
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