E3 ligase Ligand 8 |
| Katalog-Nr.GC35933 |
E3-Ligase Ligand 8 ist ein Ligand fÜr E3-Ubiquitin-Ligase. E3-Ligase-Ligand 8 kann mit dem Liganden fÜr Protein durch einen Linker verbunden werden, um PROTACs zu bilden. PROTACs sind Induktoren des Ubiquitinierungs-vermittelten Abbaus von krebsfÖrdernden Proteinen.
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Cas No.: 1225383-33-4
Sample solution is provided at 25 µL, 10mM.
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E3 ligase Ligand 8 is a ligand for E3 ubiquitin ligase. E3 ligase Ligand 8 can be connected to the ligand for protein by a linker to form PROTACs or SNIPERs. PROTACs are inducers of ubiquitination-mediated degradation of cancer-promoting proteins[1].
[1]. Shibata N, et al. Development of Protein Degradation Inducers of Androgen Receptor by Conjugation of Androgen Receptor Ligands and Inhibitor of Apoptosis Protein Ligands. J Med Chem. 2018 Jan 25;61(2):543-575.
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