F-1 |
| Katalog-Nr.GC36021 |
F-1 ist ein potenter dualer ALK- und ROS1-Inhibitor, der Phospho-ALK und seine relativ nachgeschalteten Signalwege unterdrÜckt, mit IC50-Werten von 2,1 nM, 2,3 nM, 1,3 nM und 3,9 nM fÜr ALKWT, ROS1WT, ALKL1196M bzw. ALKG1202R.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2244775-31-1
Sample solution is provided at 25 µL, 10mM.
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F-1 is a potent ALK and ROS1 dual inhibitor, suppresses phospho-ALK and its relative downstream signaling pathways, with IC50s of 2.1 nM, 2.3 nM, 1.3 nM and 3.9 nM for ALKWT, ROS1WT, ALKL1196M and ALKG1202R, respectively[1].
[1]. Guo M, et al. Dual potent ALK and ROS1 inhibitors combating drug-resistant mutants: Synthesis and biological evaluation of aminopyridine-containing diarylaminopyrimidine derivatives. Eur J Med Chem. 2018 Sep 6;158:322-333.
Average Rating: 5 (Based on Reviews and 38 reference(s) in Google Scholar.)
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