GW7604 |
Katalog-Nr.GC36201 |
GW7604 ist ein AntiÖstrogen. GW7604 ist der Metabolit von GW5638, einem hochaffinen Östrogenrezeptor (ER)-Antagonisten.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 195611-82-6
Sample solution is provided at 25 µL, 10mM.
GW7604 is an antiestrogen. GW7604 is the metabolite of GW5638, which is a high affinity estrogen receptor (ER) antagonist[1].
GW7604 is the presumed metabolite of GW5638 in breast (MCF-7) and endometrial (ECC-1) cell lines. GW7604 (0.1 nM-1 μM; 24 hours) inhibits both Estradiol (1 nM) and 4-hydroxytamoxifen (4-OHT; 10 and 100 nM) induction of TGF-alpha in a concentration related manner (1-1000 nM) in MDA-MB-231 cells[1]. Western Blot Analysis[1] Cell Line: MDA-MB-231 cells
[1]. Bentrem D, et al. Molecular mechanism of action at estrogen receptor alpha of a new clinically relevant antiestrogen (GW7604) related to tamoxifen. Endocrinology. 2001 Feb;142(2):838-46.
Average Rating: 5
(Based on Reviews and 2 reference(s) in Google Scholar.)GLPBIO products are for RESEARCH USE ONLY. Please make sure your review or question is research based.
Required fields are marked with *