Kushenol A |
| Katalog-Nr.GC36402 |
Kushenol A (Leachianone E) wird aus der Wurzel von Sophora Flavescent isoliert. Kushenol A ist ein nicht-kompetitiver Tyrosinase-Inhibitor zur Blockierung der Umwandlung von L-Tyrosin zu L-DOPA, zeigt IC50- und Ki-Werte von 1,1 μM bzw. 0,4 μM. Kushenol A ist ein Flavonoid-Antioxidans, hat hemmende Wirkungen auf Alpha-Glucosidase (IC50: 45 μM; Ki: 6,8 μM) und β-Amylase. Kushenol A wird als potenzieller Inhibitor von Enzymen bestÄtigt, die von Kosmetika zur Hautaufhellung und -alterung eingesetzt werden.
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Cas No.: 99217-63-7
Sample solution is provided at 25 µL, 10mM.
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Kushenol A is isolated from the root of Sophora flavescent, a non-competitive tyrosinase inhibitor with IC50 and Ki values of 1.1 μM and 0.4 μM, respectively[1].Kushenol A is a flavonoid antioxidant, has inhibitory effects on alpha-glucosidase and beta-amylase[2].Kushenol A is confirmed as potential inhibitors of enzymes targeted by cosmetics for skin whitening and aging[1].
[1]. Kim JH, et al. Kushenol A and 8-prenylkaempferol, tyrosinase inhibitors, derived from Sophora flavescens. J Enzyme Inhib Med Chem. 2018 Dec;33(1):1048-1054. [2]. Kim JH, et al. Glycosidase inhibitory flavonoids from Sophora flavescens. Biol Pharm Bull. 2006 Feb;29(2):302-5.
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