Mcl1-IN-9 |
Katalog-Nr.GC36559 |
Mcl1-IN-9 ist ein potenter Inhibitor der myeloischen LeukÄmie-1 (Mcl-1) mit einem IC50 von 446 nM in rekonstruierten BCR-ABL+ B-ALL-Zellen und einem Ki von 0,03 nM.
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Cas No.: 1810769-31-3
Sample solution is provided at 25 µL, 10mM.
Mcl1-IN-9 is a potent myeloid cell leukemia-1 (Mcl-1) Inhibitor with an IC50 of 446 nM in reengineered BCR-ABL+ B-ALL cells and a Ki of 0.03 nM[1]. Mcl-1|0.03 nM (Ki)
Mcl1-IN-9 inhibits growth of Mcl-1 dependent tumor cell lines in the nanomolar range[1].
Mcl1-IN-9 inhibits the growth of hematological and triple negative breast cancer xenografts at well tolerated doses[1].
[1]. Lee T, et al, Discovery of Potent Myeloid Cell Leukemia-1 (Mcl-1) Inhibitors That Demonstrate in Vivo Activity in Mouse Xenograft Models of Human Cancer. J Med Chem. 2019 Apr 25;62(8):3971-3988.
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