MC-Val-Cit-PAB-dimethylDNA31 |
| Katalog-Nr.GC36570 |
MC-Val-Cit-PAB-DimethylDNA31 ist ein Wirkstoff-Linker-Konjugat fÜr ADC mit starker AntitumoraktivitÄt unter Verwendung von DimethylDNA31, verknÜpft Über den ADC-Linker MC-Val-Cit-PAB. DimethylDNA31 hat eine wirksame bakterizide AktivitÄt gegen Persister und S. aureus in der stationÄren Phase.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1639352-06-9
Sample solution is provided at 25 µL, 10mM.
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MC-Val-Cit-PAB-dimethylDNA31 has a bioreversible linkage based on a quaternary ammonium for targeted delivery and it can improve pharmacokinetics and the therapeutic index. MC-Val-Cit-PAB-dimethylDNA31 is used for the antibody-drug conjugates (ADC) that are effective and stable in vitro and in vivo to treat various diseases or disorders[1].
[1]. Staben LR, et al. Targeted drug delivery through the traceless release of tertiary and heteroaryl amines from antibody-drug conjugates. Nat Chem. 2016 Dec;8(12):1112-1119.
Average Rating: 5 (Based on Reviews and 18 reference(s) in Google Scholar.)
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